GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs965469 | 1 | rs6037553 | chr20:3313884 | ITPA | chr20:3190056-3204504:+ | -0.25 | -6.07 | 2.6E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037554 | chr20:3315613 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.83 | 1.0E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037556 | chr20:3317890 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.83 | 1.0E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037560 | chr20:3323055 | ITPA | chr20:3190056-3204504:+ | -0.23 | -5.6 | 3.57E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037562 | chr20:3326141 | ITPA | chr20:3190056-3204504:+ | -0.23 | -5.69 | 2.21E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037567 | chr20:3332160 | ITPA | chr20:3190056-3204504:+ | -0.23 | -5.69 | 2.21E-8 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037579 | chr20:3347980 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.85 | 9.27E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037583 | chr20:3360632 | ITPA | chr20:3190056-3204504:+ | -0.24 | -5.92 | 6.32E-9 | IFN-related cytopenia |
| THCA | cis | rs965469 | 1 | rs6037590 | chr20:3374085 | ITPA | chr20:3190056-3204504:+ | -0.25 | -6.08 | 2.52E-9 | IFN-related cytopenia |
| THCA | cis | rs3740713 | 1 | rs60376560 | chr11:18453742 | LDHC | chr11:18433853-18472792:+ | -0.33 | -3.87 | 0.000123 | Amyotrophic lateral sclerosis (sporadic) |
| THCA | cis | rs73086581 | 1 | rs6037708 | chr20:3961253 | MAVS | chr20:3827449-3856761:+ | -0.23 | -3.64 | 0.000303 | Response to antidepressants in depression |
| THCA | cis | rs73201462 | 1 | rs60399786 | chr3:128062070 | EEFSEC | chr3:127872313-128127488:+ | -0.23 | -3.99 | 7.56E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs12748152 | 1 | rs60401377 | chr1:27052247 | ZDHHC18 | chr1:27153201-27182207:+ | 0.8 | 8.6 | 1.15E-16 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs6041 | 1 | rs6042 | chr13:113770068 | F7 | chr13:113760105-113774994:+ | -0.28 | -3.94 | 9.32E-5 | End-stage coagulation |
| THCA | cis | rs16958440 | 1 | rs60422392 | chr18:44621473 | HDHD2 | chr18:44633782-44676871:- | 0.28 | 5.21 | 2.84E-7 | Sitting height ratio |